Researchers have shown in a mouse model and lab cultures that a compound derived from hops reduces the abundance of a gut bacterium associated with metabolic syndrome.
are important because an estimated 35 percent of the U.S. adult population suffers from the syndrome, a common and serious condition linked with cognitive dysfunction and dementia as well as being a major risk factor for cardiovascular disease and type 2 diabetes.
OSU researchers for years have been studying the potential health benefits of xanthohumol, a chemical found in hops, and its derivatives including tetrahydroxanthohumol. The latter is commonly abbreviated to TXN, the former to XN. The researchers employed a novel computational method developed earlier by Morgun and Shulzhenko, transkingdom network analysis, to uncover TXN's mechanism for ameliorating metabolic syndrome. The analysis predicts which types of bacteria control the expression of mammalian genes connected to specific medical conditions.
Faulty glucose metabolism also negatively affects brain physiology and is at the root of multiple medical conditions including diabetes and heart disease.
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