The strong association in this meta-analysis, presented at the 2024 ECTRIMS annual meeting, were drawn from 15 multicenter phase 3 treatment trials with 16,794 participants.
COPENHAGEN — The largest and perhaps most rigorous study to demonstrate an association between the presence of comorbidities and accelerated progression of multiple sclerosis is sufficiently compelling that both the study author and an independent expert maintained clinical practice should be adjusted.
The list of comorbidities considered in this study was drawn from the International Advisory Committee on Clinical Trials in MS. It included numerous cardiometabolic comorbidities, such as hypertension, hyperlipidemia, diabetes, ischemic heart disease, cerebrovascular disease, and peripheral vascular disease.
When the EDA endpoints were evaluated individually, not even three or more comorbidities was associated with an increased rate of active lesions on MRI at the end of follow-up, but two or more and three or more comorbidities were associated with a significantly increased risk of disability worsening and relapse .
Multiple Sclerosis MS - Multiple Sclerosis Meta-Analysis Cardiometabolic Risk Cardiometabolic Risk Factors Hypertension Stroke Cerebrovascular Accident CVA - Cerebrovascular Accident Disability Atherosclerotic Heart Disease Atherosclerotic Cardiovascular Disease Coronary Heart Disease Ischemic Heart Disease Coronary Artery Disease Cerebrovascular Disease Heart
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