Common workplace fumes and dusts may heighten rheumatoidarthritis risk
Breathing in common workplace dusts and fumes from agents such as vapors, gases, and solvents may heighten the risk of developing rheumatoid arthritis, suggests research published online in theWhat's more, such vapors, gases, and solvents seem to boost the detrimental impact of smoking and genetic susceptibility to the disease, the findings indicate.
Personal job histories were provided and used to estimate the amount of individual exposure to 32 airborne workplace agents, using a validated technique. Each participant was assigned a Genetic Risk Score , according to whether they carried genes that could increase their chances of developing rheumatoid arthritis.
Analysis of the data showed that exposure to workplace agents was not only associated with a heightened risk of developing rheumatoid arthritis, but also seemed to boost that risk further by interacting with smoking and genetic susceptibility. "Triple exposure"—to a workplace agent, combined with smoking and a high GRS—was associated with a very high risk of ACPA-positive disease, ranging from 16 to 68 times higher, compared with"triple non-exposure."
They add,"Our study emphasizes the importance of occupational respiratory protections, particularly for individuals who are genetically predisposed to RA."
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