Scientists have identified promising real-world links between common HIV drugs and a reduced incidence of Alzheimer's disease.
Alzheimer's disease currently afflicts nearly seven million people in the U.S. With this number expected to grow to nearly 13 million by 2050, the lack of meaningful therapies represents a major unmet medical need. Scientists at Sanford Burnham Prebys have now identified promising real-world links between common HIV drugs and a reduced incidence of AD. The study, led by Jerold Chun, M.D., Ph.D.
The brain appears to have its own RTs that are different from those in viruses, and the research team wondered if inhibiting brain RTs with HIV drugs actually helps AD patients. Of the more than 225,000 individuals with claims data in the study, just shy of 80,000 were HIV-positive individuals over the age of 60. More than 46,000 had taken RT inhibitors during a nearly three-year observation period from 2016 to 2019. The data was obtained through a collaboration with health information technology and clinical research firm IQVIA, led by Tiffany Chow, M.D.
Chun underscores that the drugs patients took in this retrospective study were designed to counter RT activity in HIV and likely only had a limited effect on many different possible forms of the enzyme active in the brain. Additional authors on the study include Tiffany W. Chow, Mark Raupp, Matthew W. Reynolds, Siying Li and Gwendolyn E. Kaeser.
Infectious Diseases Alzheimer's Research Diseases And Conditions Alzheimer's Dementia Disorders And Syndromes Depression
United States Latest News, United States Headlines
Similar News:You can also read news stories similar to this one that we have collected from other news sources.
Mutation Helps Even Carriers of 'Alzheimer's Gene' Avoid Alzheimer'sA genetic mutation that boosts cell function could protect people against Alzheimer’s disease, even if they carry another gene mutation known to boost dementia risk.
Read more »
Alzheimer's Is More Common in Women, And This May Help Explain WhyThe Best in Science News and Amazing Breakthroughs
Read more »
Scientists Discover 17 New Genetic Variants Linked to Alzheimer’s DiseaseScience, Space and Technology News 2024
Read more »
Alzheimer’s Breakthrough: Scientists Make Revolutionary Leap in Brain Network AnalysisScience, Space and Technology News 2024
Read more »
– Scientists Shed New Light on the Woman Who Outlived Alzheimer’sScience, Space and Technology News 2024
Read more »
Alzheimer's May Spread Through Blood Transfusions, Scientists FindScience and Technology News and Videos
Read more »