Exposure to glyphosate, the most widely used herbicide, exacerbates neuroinflammation and AD-like pathology in mice, with effect lasting even after a significant pause from exposure.
Chronic exposure to glyphosate — the most widely used herbicide globally — may be a risk factor for Alzheimer’s disease , new research showed.
In addition to the possible cancer risk, multiple reports have also suggested potential harmful effects of glyphosate exposure on the brain. They dosed 4.5-month-old mice genetically predisposed to AD and non-transgenic control mice with either 0-, 50-, or 500-mg/kg of glyphosate daily for 13 weeks followed by a 6-month recovery period.
Additionally, there was a significant increase in soluble and insoluble fractions of amyloid-beta , Aβ42 plaque load and plaque size, and phosphorylated tau at Threonine 181 and Serine 396 in hippocampus and cortex brain tissue from glyphosate-exposed mice, “highlighting an exacerbation of hallmark AD-like proteinopathies,” they noted.
Alzheimer Disease Brain Blood-Brain Barrier BBB - Blood Brain Barrier Neuroinflammation Arizona Cancer Malignant Neoplasia Carcinoma Malignant Neoplasm Tissue Cancer Risk Blood Anxiety Disorder Amyloid Beta Anxiety Chemokines Cytokines Plasma
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