Simple low-doseaspirin may boost ovariancancer survival
, available online for information about how missing data were handled). Women who died during the first year or did not respond well to treatment had more aggressive cancers and other comorbidities, and those excluded due to missing questionnaires had more comorbidities and were less active than those included .We classified women as prediagnosis users if they reported use 1 and more day/week within the year prediagnosis.
The primary outcome was OC-specific survival and, for these analyses, we censored deaths from any other cause; we also assessed overall and progression-free survival . If a woman died from OC and her progression status was unknown , we assumed she experienced progression on her date of death. Because OC was the cause of death for almost all women , the results for overall survival and OVS were essentially the same; thus, we present only OVS and PFS.
To avoid immortal time bias, we ensured that exposure measurement preceded or was simultaneous with the beginning of the follow-up . In models assessing prediagnosis use, follow-up started from the date a woman started primary cancer treatment —this was the same as the date of histological diagnosis for women treated with primary surgery. In models assessing postdiagnosis use, follow-up started from the date of 12-month questionnaire.
In all NSAID models, the reference group was women who used neither aspirin nor nonaspirin -NSAIDs. We first assessed outcomes for aspirin and NA-NSAIDs separately; however, because their mechanism of action is similar, we also combined all NSAIDs to obtain greater statistical power. We applied propensity score–based inverse probability of treatment weighting to minimize confounding by observed potential confounders (
United States Latest News, United States Headlines
Similar News:You can also read news stories similar to this one that we have collected from other news sources.
New immunotherapy holds promise for ovarian cancerCAR T-cell therapy, a certain kind of cancer treatment in which the immune system's T cells are programmed to attack tumor cells, is effective in mice with ovarian cancer, according to a study published in The Journal for ImmunoTherapy of Cancer. The researchers, who work at Karolinska Institutet, hope that the discovery will pave the way for a clinical trial to see how effective the treatment is for women with the disease.
Read more »
Common heartburn drugs could speed up tuberculosis treatmentResearchers have discovered that over-the-counter drugs commonly used to treat heartburn could shorten the treatment of tuberculosis (TB). These drugs could also reduce the chances of the bacteria that causes TB from becoming drug resistant.
Read more »
Top pasta chef shares common bolognese mistake people make when cooking the mealA professional Italian chef has revealed that most people are preparing the beloved dish completely wrong.
Read more »
Bayern chief admits Cancelo may be too expensive but hopes 'common solution' can be foundBayern Munich’s sporting director has admitted the club may not be able to afford to sign Joao Cancelo on a permanent transfer this summer. The ousted Manchester City full-back signed on loan…
Read more »
Lincolnshire named UK's speeding hotspot, but police disagreeLincolnshire named UK’s speeding hotspot, but police disagree
Read more »