For patients with locally advanced prostate cancer, combined treatment with chemotherapy and hormonal therapy offers extended control of prostate-specific antigen (PSA) levels, compared to hormonal therapy alone, reports a study in the April issue of The Journal of Urology, an Official Journal of the American Urological Association.
Apr 17 2024Wolters Kluwer For patients with locally advanced prostate cancer , combined treatment with chemotherapy and hormonal therapy offers extended control of prostate-specific antigen levels, compared to hormonal therapy alone, reports a study in the April issue of The Journal of Urology ®, an Official Journal of the American Urological Association . The journal is published in the Lippincott portfolio by Wolters Kluwer.
In a 2:1 ratio, patients were randomly assigned to treatment with the chemotherapy agent docetaxel plus hormonal therapy or hormonal therapy alone. In both groups, these "neoadjuvant" treatments were followed by surgery . Addition of chemotherapy prolongs time to rising PSA levels Both groups had good pathologic responses: the cancer was "downstaged" before surgery in 65% of patients assigned to chemohormonal therapy and 48% of with hormonal therapy only. The two groups also had similar rates of minimal residual disease – only a small number of cancer cells remaining after treatment.
Median time to rising PSA levels was 17 months with chemohormonal therapy versus 14 months with hormonal therapy alone. Patients receiving chemotherapy also had a higher treatment-free survival rate: 8.5% required no further prostate cancer treatment through five years' follow-up. The two groups had similarly low complication and adverse event rates.
Chemotherapy Hormone Prostate Prostate Cancer Antigen Clinical Trial Docetaxel Healthcare Hormonal Therapy Prostatectomy Prostate-Specific Antigen Radical Prostatectomy Surgery Technology Tumor Urology
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