A method combining genetics, symptoms, and patient characteristics is moderately successful.
A novel method combining genetic variants, symptoms, and patient characteristics is moderately successful at predicting which primary care patients are at high risk of developing within the next 2 years — without the benefit of a faecal immunochemical test . Up to 16% of primary care patients are non-compliant with FIT, which is the gold standard for predicting CRC.This study was retrospective cohort of 50,387 UK Biobank participants reporting a CRC symptom in primary care at age ≥ 40 years.
The primary outcome was the risk model's performance in classifying a CRC case according to a statistical metric, the receiver operating characteristic area under the curve. Values range from 0 to 1, where 1 indicates perfect discriminative power and 0.5 indicates no discriminative power.The cohort of 50,387 participants was found to have 438 cases of CRC and 49,949 controls without CRC within 2 years of symptom reporting.
The polygenic risk score alone had good ability to distinguish cases from controls because 1.45% of participants in the highest quintile and 0.42% in the lowest quintile were later diagnosed with CRC.
Colorectal Cancer (CRC) Primary Care Genomics Genomic Medicine Cancer Malignant Neoplasia Carcinoma Malignant Neoplasm Genetic Testing Genetics UK Site Content United Kingdom Site Content United Kingdom UK Hospital Records Electronic Health Records Electronic Health Record EHR Change In Bowels Hospitals Rectal Bleeding Rectal Hemorrhage Triage
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