The findings come from a retrospective review of Mayo Clinic patients.
INDIANAPOLIS — Colchicine is an effective treatment for most pediatric patients with complex aphthous stomatitis , results from a small retrospective study showed.
Shah, in collaboration with Hilary Kunkel, MD, Nessa Aghazadeh, MD, and Megha Tollefson, MD, of the Department of Dermatology, Mayo Clinic, Rochester, Minnesota, retrospectively reviewed the charts of 20 children diagnosed with CAS who were treated with, an antiinflammatory drug often used to treat gout, at the clinic between 2000 and 2023. Treatment responses were defined as no response, partial response, and complete response.
Ulcers were most commonly located in the buccal mucosa , followed by the gingiva , the mucosal lip , and the palate . Nearly all patients reported that the CAS caused difficulties with eating or drinking. Other effects on their quality of life included weight loss , bleeding , and difficulty brushing teeth ."I was surprised by how much CAS impacts pediatric patients' quality of life," Shah said.
The researchers had follow-up data on responses to colchicine for 14 of the 20 patients. Of these, 12 had symptom improvement, five had a complete response, eight had a partial response, and one did not respond. Nine patients experienced side effects. Of these, six had diarrhea, two had nausea, and one had constipation.
"Colchicine should be considered as a treatment in pediatric patients who have refractory complex aphthous stomatitis as it is generally well tolerated with minimal side effects," Shah said. She acknowledged certain limitations of the study, including its single-center, retrospective design.
Oral Health Oral Medicine Dental Health Dental Oral Healthcare Oral Health Care Children Child Childhood Pediatrics Kids Aphthous Ulcer Canker Sore Aphthous Stomatitis Pediatric Dermatology Stomatitis Adverse Effects Side Effects Patient Safety Quality Of Life QOL Health Related Quality Of Life Health-Related Quality Of Life HRQOL Constipation Costiveness
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