WASHINGTON, April 28 — An arthritis drug that was being closely watched for its potential use against Covid-19 has delivered disappointing results in clinical trials, its makers said yesterday. Kevzara, which is made by Regeneron and Sanofi, does not attack the novel coronavirus but instead...
Arthritis drug Kevzara. — Image courtesy of en.50bestpharma.com
Kevzara, which is made by Regeneron and Sanofi, does not attack the novel coronavirus but instead inhibits an abnormal immune response called a “cytokine storm” that causes the lungs of the sickest patients to become inflamed, leaving them fighting for their lives on ventilators. There was, however, a ray of hope for those who were “critical,” defined as needing mechanical ventilation or high-flow oxygenation. In this group, 44 were on a placebo, 94 were given a low dose and 88 were given a high dose.
The company is separately developing an antibody cocktail that will directly target the virus and that it hopes to advance into human trials by June.
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