Many clinical trials of new cancer drugs may be inappropriately excluding some people with Duffy-null phenotype, a trait found predominantly in people of African or Middle Eastern descent, researchers report in a new study.
Clinical trials inappropriately excluding people of African/Middle Eastern descent, new research shows
The failure to account for Duffy-null phenotype also means that recommendations for many standard cancer drugs inappropriately call for less-effective doses for some individuals, researchers say. "People with the Duffy-null phenotype are equally able to fight off infections compared to others," Hantel says."The concern is that they've been excluded from clinical trials because the neutrophil blood levels that are normal for them can fall below the cut-off points for trial participation. In this study, we explored the extent to which this occurs."
"The treatment guidelines set by the National Comprehensive Cancer Network, or NCCN, are based on the clinical trials in which those drugs were tested," Hantel explains."If a trial stipulates that the dosage should be lowered or delayed if a patient's blood neutrophil count is below a certain level, doctors often use those modifications once the drug is approved as standard therapy.
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