Brock Purdy loses for first time as starter as final unbeaten records end.
San Francisco 49ers quarterback Brock Purdy scrambles away from Cleveland Browns linebacker Jeremiah Owusu-Koramoah
The end of a 15-game regular season winning streak also saw star running back Christian McCaffrey – who earlier made it 15-straight games with a touchdown – injure his oblique and rib, wide receiver Deebo Samuel leave with a shoulder injury and tackle Trent Williams suffer an ankle injury. Josh Allen engineered two lengthy scoring drives as the Buffalo Bills battled to a 14-9 victory over the New York Giants.
The Miami Dolphins are 5-1 and top of the AFC East after they came from 14 points down to beat the winless Carolina Panthers 42-21, Tua Tagovailoa throwing for 262 yards with touchdown passes to three different receivers. Detroit Lions quarterback Jared Goff throws under pressure from Tampa Bay Buccaneers defensive tackle Vita Vea
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