FDA-approved efgartigimod represents the first novel, precision mechanism of action in more than 30 years for CIDP.
MONTREAL — An open-label extension study of subcutaneous efgartigimod PH20 to treat chronic inflammatory demyelinating polyneuropathy showed durability of functional improvements to week 24, with no new safety signals.the coformulation of efgartigimod alfa and hyaluronidase-qvfc based on results of the pivotal phase 3 ADHERE study.
"Evidence supports a role for pathogenic IgG in the pathogenesis of CIDP, although in most patients, a specific antibody is currently not detectable," said Allen. In Stage B, 27.9% of participants on efgartigimod PH20 relapsed compared with 53.6% of those on placebo and 9.2% having more serious TEAEs.
Efgartigimod can be self-administered or administered by a caregiver at home. Among study participants who took part in ADHERE+, 37% were successfully trained to self-administer the infusion, with an additional 6% of caregivers completing this training, added Allen.Sara Austin, MD, a neurologist at Seton Brain and Spine Neurology and associate professor at Dell Medical School, University of Texas, Austin, Texas, said the neuromuscular community has looked forward to these results.
Chronic Inflammatory Demyelinating Polyneuropathy CIDP
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