Scientists Discover How Sound Reduces Pain in Mice The neural mechanisms through which sound blunts pain in mice have been identified by an international team of researchers. Published on July 7, 2022, in the journal Science, the findings could inform the development of safer methods to treat pain.
Sound reduces pain in mice by lowering the activity of neurons in the brain’s auditory cortex that project to the thalamus. Credit: Wenjie ZhouThe neural mechanisms through which sound blunts pain in mice have been identified by an international team of researchers. Published on July 7, 2022, in the journal, the findings could inform the development of safer methods to treat pain.
“Human brain imaging studies have implicated certain areas of the brain in music-induced analgesia, but these are only associations,” said co-senior author Yuanyuan Liu, Ph.D., a Stadtman tenure-track investigator at NIDCR. “In animals, we can more fully explore and manipulate the circuitry to identify the neural substrates involved.”
To explore the brain circuitry underlying this effect, the researchers used non-infectious viruses coupled with fluorescent proteins to trace connections between brain regions. They identified a route from the auditory cortex, which receives and processes information about sound, to the thalamus, which acts as a relay station for sensory signals, including pain, from the body.
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