Effective treatment with dupilumab may allow younger children with severe atopic dermatitis and short stature to catch up on their growth, potentially offering lifelong benefits, according to the results of a study of children aged 6-11 years.
AMSTERDAM — Children with short stature related to severe atopic dermatitis not only can have their condition effectively treated with 16 weeks of dupilumab but also may experience improved growth, bringing them back toward standard height curves, revealed a post hoc trial analysis.
He continued, however, that children at the lower percentiles of height receiving prompt treatment with dupilumab “were able to rapidly move through the centiles over the 16 weeks of the study, and that may be the window for catch-up growth…when children are growing rapidly.” “When you take the brakes off, they get to be who they are going to be,” Kirkorian added. “So I was surprised by the speed of it, but not by the fact that height was acquired.”
After 16 weeks of treatment with dupilumab, there was a much greater gain in height than that seen among those on placebo, with the most pronounced effect seen in children who had the lowest height at baseline. Indeed, among children in the lowest 25% height percentile at baseline, 30.6% on dupilumab vs 11.9% on placebo experienced an increase in height of 5 centiles or more(
“So the effect of catch-up growth, or growth through the centiles, is most marked in those who are in the 40th centile or below,” Irvine said, indicating that the “more growth restricted kids have much more potential to catch up.”Overall, Kirkorian said in the interview, the data are “convincing” and support her view that severe AD is a “terrible chronic disease that we really underappreciate.
Children Child Childhood Pediatrics Kids Atopic Dermatitis Atopic Eczema Body Mass Index BMI Bone Density Bone Mineral Density BMD Bones Quality Of Life QOL Health Related Quality Of Life Health-Related Quality Of Life HRQOL Short Stature Chronic Disease Chronic Illness Topical Corticosteroid Washington DC Washington - District Of Columbia
United States Latest News, United States Headlines
Similar News:You can also read news stories similar to this one that we have collected from other news sources.
Severe burns reported in children making TikTok-trendy ‘glass fruit’ in microwave'Glass fruit,' otherwise known as Tanghulu, has become a growing food trend on social media, but children are getting burned on the hot sugar. Doctors warn parents of the dangers.
Read more »
Guardians of the Children works to help children who have been abusedThe San Antonio chapter of the nonprofit says that in 2020, Bexar County was ranked as the third worst county in Texas for Child Abuse. Now, the volunteer motorcycle riders say they're helping kids one ride at a time.
Read more »
Man allegedly killed the mother of his children and her boyfriend, then took 3 childrenA man was arrested Monday after allegedly killing the mother of his children and her boyfriend at an apartment complex in southeast Austin. He is also accused o
Read more »
Children's Hospital of Philadelphia makes list of Best Children's Hospitals in the countryChildren's Hospital of Philadelphia (CHOP) was recently listed as one of the best pediatric hospitals in the country.
Read more »
MISSING CHILDREN: AMBER Alert issued for three missing children, suspectAUSTIN, Texas - The Texas Department of Public Safety has ussied
Read more »
Man allegedly killed the mother of his children and her boyfriend, then took 3 childrenA man was arrested Monday after allegedly killing the mother of his children and her boyfriend at an apartment complex in southeast Austin. He is also accused o
Read more »