At a short hearing on Friday, Dame Victoria Sharp, sitting with Lord Justice Holroyde, said they had refused Letby's request.
Child serial killer Lucy Letby has lost a Court of Appeal bid to challenge her murder and attempted murder convictions.
As the judges have declined to give the go-ahead for the challenge, this ruling marks the end of the appeal process for Letby. Lawyers for the former nurse, 34, were renewing efforts to bring an appeal before the panel of three judges.
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