The team utilized a technique that they believe could speed up the drug discovery process in the production of lissodendoric acid A. Organic chemists at the University of California, Los Angeles (UCLA) have synthesized the first artificial form of a molecule found in a sea sponge, which holds poten
Parkinson’s disease is a progressive neurological disorder that affects movement and mobility. It is caused by the degeneration of dopamine-producing neurons in the brain, leading to symptoms such as tremors, stiffness, slow movements, and impaired balance and coordination.
A key factor complicating the development of these synthetic organic molecules, Garg said, is called chirality, or “handedness.” Many molecules — including lissodendoric acid A — can exist in two distinct forms that are chemically identical but are 3D mirror images of each other, like a right and left hand. Each version is known as an enantiomer.
“Cyclic allenes,” Garg said, “have largely been forgotten since their discovery more than half a century ago. This is because they have unique chemical structures and only exist for a fraction of a second when they are generated.”
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