Large database study finds no increase in mortality, although other endpoints haven’t yet been reported, and the findings might not apply to those with active disease.
WASHINGTON — Immune checkpoint inhibitor therapy does not increase mortality in people with preexisting autoimmune disease s, new research has found.
“One message is that, when rheumatologists are asked by oncologists about patients with rheumatoid arthritis or vasculitis or other autoimmune diseases and whether it's safe to treat them with immune checkpoint inhibitors, this result provides some evidence that it probably is safe….
Asked to comment, session moderator Matlock Jeffries, MD, director of the Arthritis Research Unit at the Oklahoma Medical Research Foundation, Oklahoma City, toldthat he agrees the data are generally reassuring. “If one of our patients gets cancer and their oncologist wants to use a checkpoint inhibitor, we'd obviously still monitor them for complications, but we wouldn't automatically assume the combination of a checkpoint inhibitor and autoimmune disease would increase their mortality.
At a median follow-up of 250 days, the risk for mortality prior to propensity matching was 40.0% in the autoimmune disease group and 38.1% for those without, a significant difference with hazard ratio 1.07 . But after the matching, the difference was no longer significant: 39.8% vs 40.2%, respectively .
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