Scientists learn to boost the energy of the immune system’s first line of protection, the T cells that reside in tissue. It could help our bodies fight off cancer.
Tissue-resident T cells, colored blue, are seen in an intestine in an undated photo.
“Imagine a tumor as a broken up, destroyed city that has toxic fumes and toxic gasses leaking everywhere and there is no food. So when T cells arrive there, the battery that powers their functions becomes depleted very fast,” he said. Tissue-resident T cells might be soldiers for the immune system, but they have a side hustle. Making cholesterol. That cholesterol does not make the T cells stronger, but some elements produced in the same pathway can help a lot.
Goldrath said Coenzyme Q is one of the elements that helps make T cells stronger. Researchers discovered that a fungal byproduct called Zaragozic acid changed the cholesterol pathway to increase the creation of Coenzyme Q.
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