A new study by researchers at USC and UC Berkeley sheds light on how changes in lipid metabolism can impact the health of cells as they age and respond to stress. The study, 'Lipid homeostasis is essential for a maximal ER stress response,' was published in eLife on July 25, 2023.
, a structure within cells responsible for producing proteins as well as lipids, fatty compounds that play a variety of roles within the body. A properly functioning ER, sometimes called the"factory" of the cell, is essential for maintaining the quality of proteins and lipids within cells, said first author Gilberto Garcia, a postdoctoral researcher at the USC Leonard Davis School of Gerontology.
"let-767 codes for an enzyme that gets rid of toxic lipids and then converts them into good lipids," said Ryo Sanabria, assistant professor of gerontology at the USC Leonard Davis School and a co-author of the study."So if you get rid of it, then it really destroys ER health in two different ways: it accumulates the toxic product that it's supposed to get rid of, and then also you don't have the good stuff that it's supposed to turn it into.
The blockage of this response could play an important role in neurodegenerative conditions such as Alzheimer's disease, Parkinson's disease, Huntington's disease, and
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