Nature research paper: Central role of Tim17 in mitochondrial presequence protein translocation
We are providing an unedited version of this manuscript to give early access to its findings. Before final publication, the manuscript will undergo further editing. Please note there may be errors present which affect the content, and all legal disclaimers apply.The presequence translocase of the mitochondrial inner membrane represents the major route for the import of nuclear-encoded proteins into mitochondria.
Various views including regulatory and coupling functions have been reported on the essential TIM23 subunit Tim17. We mapped the interaction of Tim17 with matrix-targeted and inner membrane-sorted preproteins during translocation in the native membrane environment.
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