CAR-T cell combination therapy: the next revolution in cancer treatment - Cancer Cell International

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CAR-T cell combination therapy: the next revolution in cancer treatment - Cancer Cell International
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A Review article published in Cancer Cell International discusses different cancer treatment methods in combination with Chimeric antigen receptor (CAR)-T cell therapy and their therapeutic outcomes.

]. Hence, developing cell-intrinsic mechanisms may solve CPB-induced issues and improve the efficacy.Management or treatment of cancers is still a serious crisis worldwide, requiring more effort to find effective treatment solutions. Today, the use of combination cancer therapies has yielded promising results. Among the various immune-based therapies, CAR-T cell therapy has been proven in many studies to be effective in multiple cancers, especially hematological ones.

In recent decades emerging bridging therapies, which combine various therapeutic approaches to improve the CAR-T cell efficacy, can shed light on cancer treatment. Nevertheless, there have been limited clinical data on combinatorial strategies that can be applied with CAR-T cells. More large-scale trials are required to compare the different combinatorial therapies with each other and with monotherapy.

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