Cancers that have a deletion in the 9p21 section of their genomes tend to have worse outcomes for patients and increased resistance to immunotherapy. A new, bio-inspired drug restores the effectiveness of immune cells in fighting cancer. In mouse models of melanoma, bladder cancer, leukemia and colon cancer, the drug slows the growth of tumors, extends lifespan and boosts the efficacy of immunotherapy.
A new, bio-inspired drug restores the effectiveness of immune cells in fighting cancer, a team led by researchers at The University of Texas at Austin has found. In mouse models of melanoma, bladder cancer, leukemia and colon cancer, the drug slows the growth of tumors, extends lifespan and boosts the efficacy of immunotherapy.
Stone envisions the drug being used in combination with immunotherapies to boost their effectiveness. To create their drug candidate, Stone and his colleagues started with the helpful enzyme that's naturally produced by the body to break down MTA and then added flexible polymers. The study's other co-authors from UT are Kendra Garrison, Candice Lamb, Yuri Tanno and George Georgiou. The study's co-corresponding authors are Stone and David Kwiatkowski, a senior physician at Brigham and Women's Hospital and a professor of medicine at Harvard Medical School.
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