Can the gut microbiota and metabolome explain variation in anti-SARS-CoV-2 vaccination responses in immunosuppressed IBD patients? eBioMedicine imperialcollege gut microbiome microbiota SARSCoV2 vaccine vaccination
By Neha MathurFeb 27 2023Reviewed by Danielle Ellis, B.Sc. In a recent study published in eBioMedicine, researchers explored the connection between the metabolic function of the gut microbiota , its composition, and immune response to severe acute respiratory syndrome coronavirus 2 vaccination in inflammatory bowel disease patients.
The researchers subjected all participants to serological analyses at eight-week periods, regardless of the time of vaccination. Next, they measured antibody responses following two dose-regimen of ChAdOx1 nCoV-19 or BNT162b2 vaccine in these patients, categorized into individuals with immune responses above or below the geometric mean of the aggregate CLARITY-IBD cohort.
Post-statistical analyses of 1H NMR and UHPLC-MS data, the team also performed supervised Orthogonal Projections to Latent Structures Discriminant Analysis and unsupervised Principal Components Analysis . It helped them assess metabolite differences between study groups with disparately abundant gut metabolites reported with q value <0.2 after correction for false discovery rate .
The study results add to the growing evidence that the gut microbiota modulates vaccine-triggered immune responses. Though most participants in this study received BNT162b2 and fewer individuals received ChAdOx1 nCoV-19, all showed poorer serological response to vaccination associated with Parabacteroides.
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