Can Popular Weight Loss Drugs Lower Cancer Risk?

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Can Popular Weight Loss Drugs Lower Cancer Risk?
Malignant Breast NeoplasmBreast CarcinomaWeight Management
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GLP-1 agonists, such as Ozempic, are “almost starting to look like wonder drugs,” one expert said. But do the benefits extend to cancer prevention?

These drugs — known as glucagon-like peptide 1 agonists — can control blood sugar, spur meaningful weight loss, and, in high-risk patients, help prevent“They’re almost starting to look like wonder drugs,” said David Kaelber, MD, PhD, professor at Case Western Reserve University, Cleveland.

Given the growing list of benefits for these popular drugs, some researchers are exploring the potential role GLP-1 agonists may play in reducing cancer risk, especially the risk for obesity-related cancers.from Kaelber’s team, for instance, patients with type 2 diabetes who received a GLP-1 agonist had a lower risk for hepatocellular carcinoma than those who received other types of antidiabetic medications, particularly insulin.

An overarching issue with this type of study, Azoulay said, is that people who are prescribed GLP-1s are likely very different from those prescribed insulin, and it’s impossible to control for all of those differences. study, the differences in cancer incidence between GLP-1 users and insulin users were apparent from day 0.

One theory is that the anti-inflammatory effects of GLP-1s were partly responsible. In the trial, p atients on semaglutide showed a drop in C-reactive protein — which indicates inflammation in the body — similar to what’s observed with statin therapy. Reductions in systemic inflammation could potentially affect cancer risk, Kumar said.the normal natural killer cell functioning that tends to be disrupted in obesity. But there hasn’t been much work in this area.

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