Promising new therapies should change the mindset of primary care physicians and the general population about the possibility of an eventual cure.
"For too long, the management of psoriasis and other immune-mediated inflammatory diseases has suffered from an acceptance that improvement rather than cure is good enough. Our patients deserve greater ambition," wrote Christopher E.M. Griffiths, MD, and co-authors in a perspective article published in the
Progress in the treatment of psoriasis is undeniable. However, not everything Griffiths and colleagues discuss has come to pass, as Giampiero Girolomoni, MD, explained to. Girolomoni is a professor of dermatology and head of dermatology at the University of Verona School of Medicine in Verona, Italy.
"Controlled studies have shown that patients who respond best are those with a shorter disease duration. In all immune-mediated inflammatory diseases, the earlier you act, the easier it is to induce persistent remission. 'Persistent' may not mean for life, but for extremely prolonged periods." Drugs that block IL-23 are more effective in inducing prolonged remissions than those that block IL-17 because IL-23 acts upstream in the pathogenic cascade.
Access to systemic therapies for psoriasis is still challenging."Often these patients have a very difficult journey, and this is true worldwide, including in developed countries," Girolomoni explained."Dermatologists who care for them often hesitate, perhaps because they lack confidence in their decisions or for various other reasons.
Autoimmune Disease Remission Italy Italian Primary Care Chimeric Antigen Receptor T-Cell Therapy Chimeric Antigen Receptors Chimeric Immunoreceptors Chimeric T-Cell Receptors Artificial T-Cell Receptors CAR T Chimaeric Antigen Receptor T-Cell Therapy Chimaeric Antigen Receptors Chimaeric Immunoreceptors Chimaeric T-Cell Receptors Biologic Therapy Biologics Cytokines
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