Individuals with cocaine use disorder show greater biological aging in a key area of the brain, findings from a novel study of postmortem brain tissue suggest.
CUD is characterized by a loss of control over cocaine use and is associated with structural, functional, and molecular alterations in the human brain.
After correcting for differences in age, time since death, brain pH, and other conditions such as depressive disorder anddisorder, the researchers observed that cells in BA9 appeared biologically older in the men who had CUD. Changes in DNA methylation were especially prominent in genes that regulate the activity of neurons and the connectivity between them.
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