Cisplatin is lifesaving for many people with cancer, but acute kidney injury is a common and serious toxicity — can a tool identify those at risk?
Cisplatin is a preferred treatment for a wide range of cancers, including breast, head and neck, lung, ovary, and more. However, its side effects — particularly nephrotoxicity — can be severe. Kidney injury on cisplatin is associated withNow, in a large study using data from six US cancer centers, researchers have developed a risk algorithm to predict acute kidney injury after cisplatin administration.
The primary outcome was cisplatin-induced AKI , defined as a twofold or greater increase in serum creatinine or kidney replacement therapy within 14 days of a first dose of IV cisplatin. The primary model had a C statistic of 0.75 and showed better discrimination for CP-AKI than previously published models, for which the C statistics ranged from 0.60 to 0.68. The first author of a paper on an earlier model, Shveta Motwani, MD, MMSc, of BWH and Dana-Farber Cancer Institute in Boston, is also a coauthor of the new study.
By contrast, the new score uses KDIGO stage II and above to define AKI."This is a better choice, as we do not want to dissuade patients and doctors from choosing chemotherapy due to a fear of insignificant kidney damage," he said.
Renal Insufficiency Kidney Insufficiency Kidney Failure Renal Impairment Acute Kidney Injury AKI Acute Renal Failure Acute Kidney Failure Renal Trauma Renal Injury Kidney Trauma Kidneys Chronic Renal Failure Chronic Kidney Failure CKD - Chronic Kidney Disease Chronic Kidney Disease CKD Renal Disease Kidney Disease Kidney Disorder Renal Disorder Nephropathy
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