A new study analyzed 26 breast cancer drugs approved by the FDA between 2000 and 2023.
The monthly cost of treating disease is not associated with a patient with breast cancer surviving or the disease worsening, according to new research.
Next, the researchers broke down the listings to a sample of only anticancer drugs. They did not include non-oncology, supportive care, or diagnostic agents, meaning that gene and cell therapies were excluded. They checked each drug for all anticancer indications that were approved until June 30, 2023.
Other markings for each indication were whether the trial was direct comparator between active and inactive cancer drugs, whether the trial was placebo or no treatment, primary endpoint , randomization ratio , and crossover . In terms of how the researchers determined this in further detail, they"correlated them to OS/PFS/ESMO-MCBS," Daniel T. Michaeli explained."None of these associations were of significant magnitude," indicating that"breast cancer drugs are not priced-based on these new drugs' benefits for patients."
"Most trials are designed with the idea that PFS is a surrogate of OS. So, if a trial shows improvement in PFS, the study may conclude that the drug actually works; however, based on a weak PFS/OS correlation, that might not be true because what we really want is a drug that improves OS and/or quality of life," he continued.
Malignant Breast Neoplasm Breast Carcinoma Advanced Breast Cancer Metastatic Breast Carcinoma Metastatic Breast Cancer MBC Mbc Advanced BC Metastatic BC Metastatic Breast Cancer (MBC) MBC - Metastatic Breast Cancer Cancer Malignant Neoplasia Carcinoma Malignant Neoplasm Biologic Therapy Biologics
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