Broken brain connections, not protein clumps, may lie behind Alzheimer's, study in mice suggests

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Broken brain connections, not protein clumps, may lie behind Alzheimer's, study in mice suggests
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Researchers at St Vincent's Hospital in Sydney have achieved a breakthrough in our understanding dementia and new way forward to its treatment. Through their discovery, the team restored nerve cell connections (synapses) that are destroyed in the Alzheimer's brain, which are thought to store memory.

. By flicking the switch in the mice models we use in our research we were able to stop the brain cell connections from breaking down."For many years people have been focusing on removing amyloid from the brain as a pathway to an Alzheimer's cure but without any success.without having to remove any amyloid from the animals' brains resulting in the return of memory.

"Having shown that preventing synapse loss offers a way forward to treating Alzheimer's, our team will now accelerate work towards developing an effective treatment for this devastating disease," Prof Vissel said.Amanda L.

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