Gastric cancer remains a formidable adversary, ranking as the fifth most common cancer and the third-leading cause of cancer-related deaths worldwide, with over 1,000,000 new cases and close to 770,000 deaths each year.
National University of Singapore, Yong Loo Lin School of Medicine Sep 13 2024 In Singapore, gastric cancer ranks among the top 10 causes of cancer-related deaths and claims about 300 lives each year.
The research study, spearheaded by a team of clinicians and scientists from the National University Hospital , the National University Cancer Institute, Singapore , the Yong Loo Lin School of Medicine, National University of Singapore , the National Cancer Centre Singapore and Duke-NUS Medical School, utilized cutting-edge genomic and transcriptomic technologies to analyse a vast collection of patient samples.
Understanding the difficult terrain of peritoneal spread The new findings not only shed light on why gastric cancer cells tend to metastasise to the peritoneum, but also pave the way for the development of innovative therapies that target the cells and molecules surrounding the tumour – also known as the tumour microenvironment , potentially disrupting the cancer's ability to thrive in the peritoneum.
Promising clinical trial In a parallel development, the same research team conducted a clinical trial that showcased the safety and potential efficacy of a groundbreaking treatment approach for GCPM. The Phase I PIANO trial, published in ESMO Open, combined a minimally invasive surgical technique called Pressurised Intra-Peritoneal Aerosol Chemotherapy with systemic immunotherapy.
"The PIANO trial results are incredibly encouraging, demonstrating the potential of combining targeted therapy like PIPAC with immunotherapy to improve outcomes for patients," said Professor Jimmy So, Senior Consultant and Head of the Division of General Surgery at NUH, who led the PIANO trial. "This approach could revolutionise the treatment landscape for this challenging condition.
Gastric Cancer Research Chemotherapy Clinical Trial Colon Gastroenterology Genetic Hospital Immune System Immunotherapy Medical School Medicine Metastasis Oncology Sarcoma Surgery
United States Latest News, United States Headlines
Similar News:You can also read news stories similar to this one that we have collected from other news sources.
Chelsea facing Conference League nightmare as fixture moved 770 miles to location with freezing temperaturesThe Stamford Bridge outfit's game against Astana has been moved to the Almaty Ortalyk Stadion
Read more »
Research extends hope for gastric cancer patients with peritoneal metastasisGastric cancer remains a formidable adversary, ranking as the fifth most common cancer and the third-leading cause of cancer-related deaths worldwide, with more than 1,000,000 new cases and close to 770,000 deaths each year. In Singapore, gastric cancer ranks among the top 10 causes of cancer-related deaths and claims about 300 lives each year.
Read more »
Study charts the incidence and mortality of digestive system cancers in ChinaCancers of the digestive system mainly include esophageal, gastric, liver, gallbladder, pancreatic, and colorectal cancers.
Read more »
Chelsea’s Conference League clash moved 770 MILES to Chinese border as Blues face 18-hour trip and f...Chelsea's plans for £1bn new stadium (1)
Read more »
Researchers make breakthrough in predicting the prognosis of triple-negative breast cancerScientists at Huntsman Cancer Institute at the University of Utah (the U), the National Cancer Institute-designated cancer center for the Mountain West, have made a significant breakthrough in predicting the prognosis of triple-negative breast cancer (TNBC), a particularly aggressive disease.
Read more »
Man United get new Manuel Ugarte transfer hint after talks breakthroughManchester United are determined to get a deal over the line for Manuel Ugarte with negotiations thought to be at the final stages
Read more »