South Yorkshire Police say the arrests are part of its investigation into alleged public order offences.
Wednesday were beaten by Sunderland 3-0 at the game on Friday.
Bradley, of Blackhall Colliery, County Durham, was a Sunderland fan, who was diagnosed with neuroblastoma - a rare type of cancer - when he was 18 months old.His mother, Gemma Lowery, said in a statement through the Bradley Lowery Foundation that police had been in touch to check on her wellbeing and were taking it very seriously.
She added: "I want to thank Sheffield Wednesday, for their quick condemnation, and the support their fans have shown.Well-wishers raised more than £700,000 in 2016 to pay for Bradley to be given antibody treatment in New York, but medics then found his cancer had grown and his family was told his illness was terminal.
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