Botulinum toxin A formulations show distinct differences in onset and duration of effect in women with glabellar rhytids.
A randomized trial showed quantitative differences between four botulinum toxin A formulations among women treated for glabellar rhytids, with abo botulinum toxin A and pra botulinum toxin A having a faster onset of effect than ona botulinum toxin A and inco botulinum toxin A , and PBoNT/A showing a significantly greater effect at 3 months.
In a single-center, double-blind randomized clinical trial, 143 women aged 30-65 years were randomly assigned 1:1:1:1 to OBoNT/A, ABoNT/A, PBoNT/A, or IBoNT/A at standard doses. Their mean age was 43.5 years; most participants were White, 4.9% were Black, and 4.2% were Asian.The primary outcome was glabellar strain, measured using dynamic three-dimensional photogrammetry. The secondary outcome was patient satisfaction, assessed with FACE-Q surveys.Compared with OBoNT/A and IBoNT/A , ABoNT/A and PBoNT/A showed a significantly faster onset, with strain reduction observed at day 3 (Maximum treatment efficacy most frequently occurred at day 30, with an overall median efficacy of 88% in the total cohort and no significant difference between the treatments at day 30. Maximum efficacy was 89.3% in the OBoNT/A, 93% in the PBoNT/A, and 89.5% in the IBoNT/A groups. Increasing baseline glabellar strain severity resulted in proportionally greater improvement with treatment across all formulations. FACE-Q scores improved significantly from baseline across all groups by day 30, with most improvements lasting through 6 months and no significant differences between treatment groups. No adverse events were reported.“This randomized clinical trial demonstrated precise quantitative differences between 4 BoNT/A formulations in treating glabellar strain,” the study authors wrote, adding that the quantification of the effect of BoNT/A “provides an objective foundation to guide individualized product selection and patient education.”Limitations included reduced participant retention at the final visit and inclusion of only female participants. Differential dosing and treatment of adjoining regions were not examined.The study was funded by Evolus. Lemdani and three other authors reported receiving grants from Evolus during this study. One author also received personal fees from AbbVie and Galderma. This article was created using several editorial tools, including AI, as part of the process. Human editors reviewed this content before publication.All material on this website is protected by copyright, Copyright © 1994-2025 by WebMD LLC. This website also contains material copyrighted by 3rd parties.
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