Joyce Bischoff studies infant haemangiomas to glean insights into potential cancer drugs.
For more than 30 years, Joyce Bischoff has been the principal investigator of a laboratory, at Boston Children’s Hospital in Massachusetts, that studies infantile haemangioma. By elucidating the cellular and molecular mechanisms behind these benign tumours, which are formed by rogue proliferating blood vessels, Bischoff hopes to help develop treatments.
In 1990, an opportunity arose to join Boston Children’s Hospital as a principal investigator and Harvard Medical School in Boston, Massachusetts, as an assistant professor. It was fantastic because I was exposed to not just research on tumour angiogenesis — the proliferation of a network of blood vessels that supply oxygen and nutrients to a tumour — but also to work on infantile haemangioma. It really opened my eyes.
Now, my laboratory is doing basic science on tumour cells, but of course we want this science to be translated to the clinic. A lot of the work we’ve done involves determining how known cancer drugs function, which we hope can help us to come up with new ones. For example, in 2008, a group in France discovered, kind of by accident, that propranolol, a β-blocker that’s used to treat high blood pressure and various heart conditions, works well on haemangiomas (
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