New findings take the field of Parkinson's disease another step closer to the holy grail of early diagnosis before clinical symptoms and neuronal loss occur.
up to 7 years before the development of motor symptoms or dementia with Lewy bodies, results of a new study suggest.
They then constructed a targeted, mass spectrometry proteomic assay with 121 proteins and applied it to plasma samples from 99 patients with de novo PD and 36 healthy controls, and then validated the assay in 41 patients with other neurologic diseases and in 18 patients with premotor isolated The model included eight proteins: GRN, MASP2, HSPA5, PTGDS, ICAM1, complement C3, DKK3, and SERPING1.
"My lab and my collaborators have been working on discovering Parkinson's biomarkers using cerebral spinal fluid, but we found it is quite challenging," he said."But what found is they could discover some biomarkers from serum. This is much easier to get samples from patients and less invasive. Then, they could even predict Parkinson's up to 7 years before the motor symptom onset. So, I think it is a quite an impressive study.
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