The agent is the first BiTE approved for consolidation regardless of MRD status.
blinatumomab as consolidation for CD19-positive, Philadelphia chromosome–negative B-cell precursor acute lymphoblastic leukemia in both children and adults.for relapsed or refractory disease and disease in the first or second complete remission with measurable residual disease of ≥ 0.1%.
Three-year overall survival was 84.8% in the blinatumomab group vs 69% with chemotherapy alone. Five-year OS was 82.4% with blinatumomab vs 62.5%., MD, a leukemia specialist at the University of Pennsylvania, Philadelphia, called the OS improvement"remarkable" and said the new approval of blinatumomab"redefines the standard of care for patients with B-ALL."
Five‑year OS was 78.4% with blinatumomab vs 41.4% with chemotherapy. Five-year relapse-free survival was 61.1% in the blinatumomab group vs 27.6%. In the E1910 study, ≥ 20% of blinatumomab subjects developed neutropenia, thrombocytopenia, anemia, leukopenia, headache, infection, nausea, lymphopenia, diarrhea, musculoskeletal pain, and tremor. In Study 20120215, ≥ 20% of blinatumomab patients developed pyrexia, nausea, headache, rash, hypogammaglobulinemia, and anemia.
Acute Leukaemia Chemotherapy Combination Chemotherapy Thrombocytopenia Toxicology Toxicity Poisoning Toxins Pain Management Headache Acute Lymphoblastic Leukemia Acute Lymphocytic Leukemia ALL Acute Lymphoblastic Leukaemia Acute Lymphocytic Leukaemia Anemia Anaemia Children Child Childhood Pediatrics Kids Leukemia Leukaemia Blood Cancer Nausea Remission
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