A study found Black metastatic breast cancer patients with PIK3CA mutations were less likely to receive targeted therapy or join trials than White patients.
Black metastatic breast cancer patients with PIK3CA mutations were less likely to receive targeted therapy and less likely to be enrolled in clinical trials than White patients and had shorter overall survival, according to a retrospective cohort study. Black and White patients were equally likely to receive other drugs that did not require genomic testing.
In terms of PI3K inhibition, PIK3CA mutations are found in about 40% of patients with HR-positive HER2-negative metastatic breast cancer. Alpelisib is FDA-approved as a targeted therapy for these patients, she said. The analysis showed inequities in both treatment and clinical trial enrollment. There were no differences between groups in the use of CDK4/6 or mTOR inhibitors, which do not require a genomic profile, the researchers noted, but Black patients with PIK3CA single nucleotide variants were significantly less likely than White patients to use PI3K inhibitors , despite no difference in PIK3CA mutations between groups .
Metastatic Breast Carcinoma Metastatic Breast Cancer MBC Mbc Advanced BC Metastatic BC Metastatic Breast Cancer (MBC) MBC - Metastatic Breast Cancer Breast Cancer Malignant Breast Neoplasm Breast Carcinoma Targeted Therapy Targeted Cancer Therapy Biologic Therapy Biologics Liquid Biopsy Fluid Biopsy Fluid Phase Biopsy Cancer Blood Test Cancer Saliva Test
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