Bivalent mRNA vaccine is moderately effective in preventing COVID-19 Coronavirus Disease COVID Vaccine Bivalent mRNA medrxivpreprint ClevelandClinic
By Suchandrima BhowmikDec 22 2022Reviewed by Benedette Cuffari, M.Sc. A new study posted to the preprint server medRxiv* assesses the real-world efficacy of the novel bivalent coronavirus disease 2019 vaccine.
Despite the benefits of these vaccines, many people in resource-poor countries could not be vaccinated in a timely manner, which subsequently led to several COVID-19 waves worldwide. The continuous evolution of the severe acute respiratory syndrome coronavirus 2 , the virus responsible for COVID-19, led to the emergence of various viral variants that exhibited superior transmissibility and immune evasive properties.
About the study The current study involved the recruitment of Cleveland Clinic Health System employees on September 12, 2022, when the bivalent vaccine first became available. Information was collected on the gender, age, job location, and job categorization of all participants. A total of 10.804 employees received the bivalent vaccine, 9,595 of whom received the Pfizer vaccine, and 1,178 received the Moderna vaccine. A total of 2,452 employees tested positive for COVID-19 during the study period.
Moreover, people with prior SARS-CoV-2 exposure in the last six to nine months were twice as likely to be re-infected. In contrast, those with previous exposure in the past nine to 12 months were at a 3.5-fold greater risk of contracting COVID-19 than those infected within the last 90 days. Limitations The study has certain limitations. For example, individuals with previously unrecognized infections might have been misclassified, underestimating the bivalent vaccine's protective benefits. Additionally, those receiving the bivalent vaccine were more likely to get tested on symptom appearance, which leads to a disproportionate detection of infections.
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