These gene-editing startups are aiming to solve one of CRISPR's biggest problems. Here's how they could upend biotech in 2022.
These companies have raised hundreds of millions to improve gene-editing technology.A new crop of biotechs is looking to either improve CRISPR or develop new gene-editing techniques — and 2022 may be a crucial year in proving their value.
These companies, most of them privately held and founded in the past few years, have persuaded investors to bet hundreds of millions that they can develop editing systems that are better than CRISPR. The startups are pitching themselves as developing the next generation of gene-editing technology, but they need to show investors what they bring to the table that the original CRISPR companies don't.
The initial 2012 discovery uses an enzyme called Cas9, a protein that cuts DNA. While that was the first DNA-cutting enzyme discovered, a range of startups are betting they can do better, including Mammoth Biosciences, Metagenomi, Scribe, and Arbor Biotechnologies. Cas9 is so big in size that it's harder to package and ultimately deliver into cells, which can make it more challenging to treat certain diseases.
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