Biophysical Modeling of SARS-CoV-2 Assembly: Genome Condensation and Budding

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Biophysical Modeling of SARS-CoV-2 Assembly: Genome Condensation and Budding
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Coronavirus formation is successfully modeled UCRiverside

The COVID-19 pandemic caused by the Severe Acute Respiratory Syndrome Coronavirus 2 has spurred unprecedented and concerted worldwide research to curtail and eradicate this pathogen.

CoV-2 has four structural proteins: Envelope , Membrane , Nucleocapsid , and Spike , which self-assemble along with its RNA into the infectious virus by budding from intracellular lipid membranes. In this paper, we develop a model to explore the mechanisms of RNA condensation by structural proteins, protein oligomerization and cellular membrane–protein interactions that control the budding process and the ultimate virus structure.

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