A study published in MicrobiomeJ presents an extensive biogeographical survey of sub-Saharan top-soil microbiomes and a model to predict how soil microbial biodiversity in this region might be affected by future climate change scenarios. Read the paper:
Fox J, Weisberg S. An R companion to applied regression. 3rd ed. Sage; 2019.The authors wish to thank their institutions for continued support for their research activities. We particularly acknowledge the South African Department of Higher Education and Training for administration of the USAID grant, as well as the NRF Foundational Biodiversity Program .
DA Cowan, PH Lebre, T Coetzee, K Jordaan, G Kamgan-Nkuekam, M Ortiz, J-B Ramond, A Valverde, G Varliero & S VikramCER Amon & A Zeze Biodiversity Research Centre, Department of Agriculture and Natural Resources Sciences, Namibia University of Science and Technology, Windhoek, NamibiaCentro de Biotecnologia, Universidade Eduardo Mondlane, Maputo, MozambiqueDepartment of Biotechnology and Biochemistry, University of Zimbabwe, Harare, ZimbabweDepartment of Plant and Soil Sciences, University of Pretoria, Pretoria, South AfricaDepartment of Environmental Science, University of Botswana, Gaborone, BotswanaScotland’s Rural...
Departamento de Genética Molecular Y Microbiología, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Santiago, ChileDepartment of Biochemistry, Genetics and Microbiology, University of Pretoria, Pretoria, South AfricaG Maggs-Kölling, E Marais & M SeelyDepartment of Biology, Colorado State University, Fort Collins, USA
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Postnatal exposure to ambient air pollutants is associated with the composition of the infant gut microbiota at 6-months of ageEpidemiological studies in adults have shown that exposure to ambient air pollution (AAP) is associated with the composition of the adult gut microbiome, but these relationships have not been exami...
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Orally administered Odoribacter laneus improves glucose control and inflammatory profile in obese mice by depleting circulating succinate - MicrobiomeBackground Succinate is produced by both human cells and by gut bacteria and couples metabolism to inflammation as an extracellular signaling transducer. Circulating succinate is elevated in patients with obesity and type 2 diabetes and is linked to numerous complications, yet no studies have specifically addressed the contribution of gut microbiota to systemic succinate or explored the consequences of reducing intestinal succinate levels in this setting. Results Using germ-free and microbiota-depleted mouse models, we show that the gut microbiota is a significant source of circulating succinate, which is elevated in obesity. We also show in vivo that therapeutic treatments with selected bacteria diminish the levels of circulating succinate in obese mice. Specifically, we demonstrate that Odoribacter laneus is a promising probiotic based on its ability to deplete succinate and improve glucose tolerance and the inflammatory profile in two independent models of obesity (db/db mice and diet-induced obese mice). Mechanistically, this is partly mediated by the succinate receptor 1. Supporting these preclinical findings, we demonstrate an inverse correlation between plasma and fecal levels of succinate in a cohort of patients with severe obesity. We also show that plasma succinate, which is associated with several components of metabolic syndrome including waist circumference, triglycerides, and uric acid, among others, is a primary determinant of insulin sensitivity evaluated by the euglycemic-hyperinsulinemic clamp. Conclusions Overall, our work uncovers O. laneus as a promising next-generation probiotic to deplete succinate and improve glucose tolerance and obesity-related inflammation. Video Abstract
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R driver 'almost crashes into lorry while three times over drink-driving limit'The female driver passed her test four weeks ago and, according to police, just avoided the vehicle due to the 'alertness and very skilful driving' of the lorry driver.
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Covid: Millions invited for booster jabs from MondayHealth bosses predict a resurgence of the virus and flu during the autumn and winter.
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