Central obesity demonstrated a stronger association with colorectal cancer risk than general obesity measured using body mass index, according to a large UK cohort study.
Individuals with normal body mass index measurements may still face an increased risk for colorectal cancer if they have central obesity, characterized by excess fat around the abdomen.General obesity, often measured using BMI , is a recognized risk factor for CRC, but how much of this association is due to central obesity is unclear.
Researchers assessed the associations between BMI, waist-to-hip ratio , and waist circumference with CRC risk and the degree of independence among these associations in patients aged 40-69 years recruited in the UK Biobank cohort study from 2006 to 2010.Researchers included 460,784 participants , of whom 67.1% had either overweight or obesity, and 49.4% and 60.5% had high or very high WHR and WC, respectively.Every SD increase in WHR showed a stronger association with CRC risk than in BMI .
After adjustment for BMI, the association between WHR and CRC risk became slightly attenuated while still staying robust ; however, after adjusting for WHR, the association between BMI and CRC risk became substantially weakened . WHR showed strongly significant associations with CRC risk across all BMI categories, whereas associations of BMI with CRC risk were weak and not statistically significant within all WHR categories.
Central obesity demonstrated consistent associations with both colon and rectal cancer risks in both sexes before and after adjustment for BMI, whereas BMI showed no significant association with CRC risk in women or with rectal cancer risk after WHR adjustment.
Colorectal Cancer (CRC) Body Mass Index BMI Obesity Obese Cancer Risk Cancer Malignant Neoplasia Carcinoma Malignant Neoplasm Malignant Rectal Neoplasm Rectal Cancer Cancer Of The Rectum Rectal Carcinoma UK Site Content United Kingdom Site Content United Kingdom UK Germany German
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