A phase 3 clinical trial investigated the effect of the BCG vaccine administered during active infection on the progression of COVID-19 in adults with mild or moderate symptoms. The study followed up patients at 6 and 12 months to assess long-COVID symptoms, showing potential benefits of the vaccine in preventing long-term effects.
Administering the Bacillus Calmette-Guérin vaccine during the active phase of COVID-19 may help protect against the development of long COVID.A phase 3 clinical trial initiated in early 2020 investigated the effect of the BCG vaccine injected during active infection on COVID-19 progression in adults with mild or moderate COVID-19. The current study summarizes the 6- and 12-month follow-up data with a focus on long-COVID symptoms.
Patients who tested positive for severe acute respiratory syndrome coronavirus 2 were randomly assigned to receive either 0.1 mL of intradermal BCG or 0.9% saline placebo within 14 days of symptom onset and were followed up at 7, 14, 21, and 45 days and at 6 and 12 months postinjection. Overall, 157 BCG and 142 placebo recipients completed the 6-month follow-up, and 97 BCG and 95 placebo recipients completed the 12-month follow-up.
The researchers primarily assessed the effect of the BCG vaccine on the development of the symptoms of long COVID at 6 and 12 months.Hearing problems were less frequent among BCG recipients at 6 months compared with those who received placebo , and the National Council for Scientific and Technological Development-Research Productivity. The authors declared no conflicts of interest.
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BCG VACCINE LONG COVID CLINICAL TRIAL CORONAVIRUS IMMUNE RESPONSE
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