Bat stem cells reveal how bats survive in a virus-filled environment StemCells Virus Virology Bat Pluripotent bats differentiation epigenetics coronaviruses evolution CellCellPress LSHTM ucddublin IcahnMountSinai
By Dr. Priyom Bose, Ph.D.Mar 15 2023Reviewed by Danielle Ellis, B.Sc. Bats inhabit diverse ecological niches, accounting for one-fifth of all living mammalian species. They feed on fruits, nectar, arthropods, leaves, fish, small vertebrates, and blood. Its unique ability to fly, combined with the ability to navigate in darkness using laryngeal echolocation, makes bats fascinating mammals.
Omics eBook Compilation of the top interviews, articles, and news in the last year. Download a free copy Bats are asymptomatic and tolerant viral hosts primarily due to modulation of the innate immune response. Although bats have small genomic sizes, they contain a large diversity of ancient and contemporary viral insertions of retroviral and non-retroviral origin. This is the reason why bats demonstrate tolerant evolutionary history with their viral pathogens.
It is interesting to observe how genomic adaptations in the bat immune system resemble viruses' process of dismantling the host responses. Viruses can effectively change host cell processes to their advantage and transform host cells into virus-producing factories. At present, there are no reliable cellular models to study bat biology or how they interact with viral infections. Therefore, the authors created induced pluripotent stem cells from two species of bats, i.e., Rhinolophus ferrumequinum and Myotis myotis .
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