Base editing: Revolutionary therapy clears girl's incurable cancer

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Base editing: Revolutionary therapy clears girl's incurable cancer
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New way of altering DNA is used to engineer an 'exciting', experimental therapy for a 13-year girl.

What happened next would have been unthinkable just a few years ago and has been made possible by incredible advances in genetics.invented only six years agoBases are the language of life. The four types of base - adenine , cytosine , guanine and thymine - are the building blocks of our genetic code. Just as letters in the alphabet spell out words that carry meaning, the billions of bases in our DNA spell out the instruction manual for our body.

The final stage of genetic modification instructed the T-cells to go hunting for anything with the CD7 marking on it so that it would destroy every T-cell in her body - including the cancerous ones. That's why this marking has to be removed from the therapy - otherwise it would just destroy itself. He said this genetic manipulation was a "very fast-moving area of science" with "enormous potential" across a range of diseases.

Alyssa spent 16 weeks in hospital and couldn't see her brother, who was still going to school, in case he brought germs in. "It's crazy. It's just amazing I've been able to have this opportunity, I'm very thankful for it and it's going to help other children, as well, in the future." "To have this extra year, this last three months when she's been home, has been a gift in itself," said Kiona.

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