A man, believed to be in his 30s, was pronounced dead at the scene, said police.
The Metropolitan Police was called to reports of a man injured in Linton Road, Barking, at about 04:30 BST on Sunday.
No arrests have been made, the force said, and the road has been closed while a crime scene remains in place.The man's next of kin have been informed and enquiries into the circumstances continue, the force added.
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