BARDA awards up to $500 million in Project NextGen funding for vaccine clinical trials
Project awards made under new Rapid Response Partnership Vehicle will evaluate novel COVID-19 vaccine candidates
“We learned a lot during the COVID-19 pandemic that we can use to better prepare for future public health crises. That includes finding new ways to administer vaccines to make it even easier for everyone to protect themselves from illness,” said HHS Secretary Xavier Becerra. “We are making progress on the development of cutting-edge treatments, such as vaccines administered as a nasal spray or as a pill.
Approximately $34 million to Castlevax, part of the Mount Sinai Health System in New York City, developing an intranasal vaccine candidate, CVAX-01. Currently approved COVID-19 vaccines are administered intramuscularly and, while extremely effective, are limited in their capacity to induce a robust immune response in mucosal areas such as the mouth, nose, and gut, where the SARS-CoV-2 virus first enters the body. Successful development of intranasal and oral vaccines would provide safe, effective, needle-free vaccines that are easier-to-administer options with the potential to improve vaccine access.
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