Scientists discover that antibiotic resistance in bacteria can hinder their survival in low magnesium environments, offering a potential new strategy to fight infection without drugs.
US and Spanish researchers have now discovered at least some bacteria pay a steep price for their resistance – a cost that we may be able to exploit to fight infection. 'We can take advantage of this cost to suppress the establishment of antibiotic resistance without drugs or harmful chemicals.
' Exploring why bacteria with resistance factors don't necessarily dominate their non-resistant relatives, University of California, San Diego biologist Eun Chae Moon and colleagues discovered an example of protection that comes at a cost, impeding the bacteria's ability to survive when levels of magnesium are low. 'While we often think of antibiotic resistance as a major benefit for bacteria to survive, we found that the ability to cope with magnesium limitation in their environment is more important for bacterial proliferation,' Süel Depriving environments of magnesium could counter the bacteria's ability to thrive. And because unmutated strains don't share the same flaw, reducing the key nutrient shouldn't adversely impact bacteria needed for a healthy microbiome. Molecular structure of a ribosome showing potential areas of change, with warmer colors indicating flexibility and cooler colors highlighting rigidity in the structure., the micro machines in cells that create proteins. The ions also play an important role in the use of ATP that powers our cells.both protects the strain against antibiotics and tightly binds to the charged magnesium atom, leaving less for ATP to use for producing cellular energ
Antibiotic Resistance Bacteria Magnesium Infection Microbiome
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