Echo findings in heart failure patients with preserved or mildly reduced ejection fraction treated with an atrial shunt shed light on why only certain patients respond to therapy.
Findings from an echocardiographic study of patients with heart failure with preserved or mildly reduced ejection fraction treated with an atrial shunt have shed more light on mechanisms that explain why certain patients appear to respond to the shunt therapy while others do not.In the REDUCE LAP-HF II trial, 626 patients with heart failure with preserved ejection fraction or mildly reduced ejection fraction were randomized to receive an atrial pump or a sham control.
Shunt treatment also increased right ventricular and right atrial volumes but had no effect on right ventricular systolic function, pulmonary artery pressure, or right atrial pressure compared with sham. "In responders to the atrial shunt blood is shunted from the left atrium to the right atrium/ventricle and it is then able to get to the pulmonary vasculature and back to the left side of the heart to be pumped out to the body. This is because the pulmonary vasculature and the right side of the heart are healthy."
"It is very clear that this echocardiographic analysis supports and explains a lot about the phenotypes we have already identified as potential responders and nonresponders to atrial shunt therapy."
Cardiovascular Imaging Cardiac Imaging CV Imaging Interventional Cardiology Devices And/Or Drugs Interventional Cardiology Device Interventional Cardiology Drug Heart Cardiac Rhythm Management CRM Heart Rhythm Management Arrhythmia Atrial Fibrillation AF Afib A-Fib Afib Afib Atrial Fib Atrial Fibrillation (AF) Atrial Fibrillation (A-Fib) AF - Atrial Fibrillation
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