Researchers aimed to evaluate the efficacy of combining atezolizumab with targeted therapy based on tumor mutation status.
Atezolizumab combined with targeted therapy improved median overall survival to 19 months in patients with anaplastic thyroid carcinoma . The longest survival was observed in theThe median overall survival for ATC has historically been 5 months, with previous research having shown limited efficacy of single-agent targeted therapy and immunotherapy.
A phase 2 trial was conducted at a single-center, tertiary institution with parallel cohorts, enrolling 43 patients with ATC. The study aimed to evaluate the efficacy of combining atezolizumab with targeted therapy based on tumor mutation status. The rationale for the combination strategy was to achieve a faster onset of action and potentially synergize with immunotherapy.
The primary outcome was median overall survival, with secondary outcomes including progression-free survival and overall response rate. Patients were enrolled from August 3, 2017, to July 7, 2021, and the analysis was conducted in September 2023. Those included in the study."This nonrandomized clinical trial found that mutation-directed targeted therapy in combination with PD-L1 inhibitor immunotherapy is a promising strategy to extend OS in patients with ATC. Further studies in patients with non-The study was led by Maria E. Cabanillas, MD, University of Texas MD Anderson Cancer Center in Houston.
This article was created using several editorial tools, including AI, as part of the process. Human editors reviewed this content before publication.
Thyroid Carcinoma Cancer Of The Thyroid Biologic Therapy Biologics Thyroid Disorder Thyroid Disease Thyroid Dysfunction Malignant Head And Neck Neoplasm Head And Neck Cancer Head And Neck Cancer (HNC) Targeted Therapy Targeted Cancer Therapy Anaplastic Thyroid Carcinoma Anaplastic Carcinoma Of The Thyroid Cancer Malignant Neoplasia Carcinoma Malignant Neoplasm
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